Biological Activity |
Endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo . |
Biochem/physiol Actions |
Neurotransmitter. |
Purification Methods |
5-HT is purified by recrystallisation from EtOH/Et2O or Et2O to give the hygroscopic salt. Store it in the dark as it is light sensitive. The free base has m 84-86o (from Et2O). The 5-benzyloxy derivative has m 84-86o (from Et2O). [Ek & Witkop J Am Chem Soc 76 5579 1954, Hamlin & Fischer J Am Chem Soc 73 5007 1951.] The picrate 1H2O has m 196-197.5o (dec with sintering at 160-165o) after crystallisation from Et2O. Serotonin is a natural neurotransmitter [Chuang Life Sci 41 1051 1987]. [Beilstein 22/12 V 16.] |
InChI:InChI=1/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
The invention discloses a preparation me...
The invention discloses a method for pre...
C10H10N2O3
serotonin hydrochloride
Conditions | Yield |
---|---|
C10H10N2O3;
With
hydrogen;
In
methanol;
at 30 ℃;
Autoclave;
Industrial scale;
With
hydrogenchloride;
In
methanol; water;
Autoclave;
Industrial scale;
|
91% |
tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate
serotonin hydrochloride
Conditions | Yield |
---|---|
With
hydrogenchloride;
In
methanol; water; ethyl acetate;
at 25 ℃;
for 0.166667h;
|
tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate
tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate
L-cystine
5,5′-dihydroxy-4,4′-bitryptamine
4,5-dihydroxytryptamine