

The invention provides a synthesis metho...
A facile, universal and economical metho...
The invention relates to a preparation m...
The invention relates to a preparation m...

allyl 3-((3-(benzyloxy)-2-(ethoxycarbonyl)-4-oxopyridin-1(4H)-yl)amino)morpholine -4-formate

![7-(benzyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido [2,1-f][1,2,4]triazine-6,8-diketone](/upload/2024/8/7eedec1f-99ae-4654-8f8f-d34c3c39a2e3.png)
7-(benzyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido [2,1-f][1,2,4]triazine-6,8-diketone
| Conditions | Yield |
|---|---|
|
With morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 20 ℃; for 2h;
|
100% |
|
With morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 20 ℃; for 2h;
|
100% |
|
With morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; for 3h; Inert atmosphere;
|
90% |
|
With morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 20 ℃; for 2h;
|
|
|
With morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 20 ℃; for 2h;
|
418 mg |
|
With morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 20 ℃; for 2.5h;
|
|
|
With morpholine; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 20 ℃; for 2h;
|
418 mg |
C22H23N3O6

![(R)-7-(benzyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]pyrano[4,3-c]pyrido[2,1-f][1,2,4]triazine-6,8(1H,3H)-dione](/upload/2024/8/7420fd12-62d8-4adf-8e29-2e3a9c976a74.png)
(R)-7-(benzyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]pyrano[4,3-c]pyrido[2,1-f][1,2,4]triazine-6,8(1H,3H)-dione
| Conditions | Yield |
|---|---|
|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 30 ℃; for 0.5h;
|
93.46% |
|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 20 ℃; for 0.666667h;
|
91% |
|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 20 ℃; for 0.5h;
|
90% |
|
C22H23N3O6; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 20 ℃; for 0.5h;
In di-isopropyl ether; at 20 ℃; for 0.5h;
|
89.9% |
|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 20 ℃; for 0.5h;
|
89.9% |
|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 20 ℃; for 0.5h;
|
89.9% |
|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 20 ℃; for 0.5h;
|
89.9% |
|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; ethyl acetate; at 20 - 30 ℃; for 1h;
|
45% |

3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylate ethyl ester

1‐amino‐3‐(benzyloxy)‐4‐oxo-1,4-dihydropyridine‐2‐carboxylic acid ethyl ester

3-(benzyloxy)-1-((tert-butoxycarbonyl)amino)-4-oxo-1,4-dihydropyridine-2-carboxylic acid ethyl ester

methyl 1-((tert-butoxycarbonyl)amino)-3-(benzyloxy)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

(R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione