The invention discloses a preparation me...
PROBLEM TO BE SOLVED: To provide a compo...
The invention relates to the compounds o...
The present invention relates to compoun...
5-acetyl-8-benzyloxy-1H-quinolin-2-one
8-benzyloxy-5-[2-chloroacetyl]-1H-quinolin-2-one
Conditions | Yield |
---|---|
5-acetyl-8-benzyloxy-1H-quinolin-2-one;
With
N,N,N-trimethylbenzenemethanaminium dichloroiodate;
In
methanol; 1,2-dichloro-ethane;
Heating / reflux;
With
hydrogenchloride;
In
tetrahydrofuran; water;
|
84% |
With
benzyltrimethylammonium iododichloride;
In
methanol; dichloromethane;
Heating / reflux;
|
84% |
With
N,N,N-trimethylbenzenemethanaminium dichloroiodate;
In
acetic acid;
at 65 - 70 ℃;
|
|
With
N,N,N-trimethylbenzenemethanaminium dichloroiodate;
In
acetic acid;
at 65 - 70 ℃;
|
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one
8-benzyloxy-5-[2-chloroacetyl]-1H-quinolin-2-one
Conditions | Yield |
---|---|
With
silver carbonate; lithium chloride;
In
acetone;
at 45 ℃;
for 72h;
Inert atmosphere;
|
99% |
5-acetyl-8-benzyloxy-1H-quinolin-2-one
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one
2-methoxy-phenylamine
N-(2-methoxyphenyl)-3-phenylacrylamide
8-benzyloxy-5-(2-chloro-1-hydroxy-ethyl)-1H-quinolin-2-one
8-benzyloxy-5-((S)-2-chloro-1-hydroxy-ethyl)-1H-quinolin-2-one